Volume: 1 Issue: 1
Year: 2025, Page: 40-46,
Received: July 10, 2024 Accepted: Feb. 18, 2025 Published: April 22, 2025
Clerodendrum serratum (L.) Moon, commonly known as "Bharangi" in Ayurvedic medicine, has been traditionally used for its therapeutic properties. The goal of this study is to determine if the ethanolic extract of Clerodendrum serratum (CS) leaves may prevent myocardial infarction (MI) in rats that have been caused by isoprenaline. Male Wistar rats were pre-treated with 200 and 400 mg/kg b.wt of CS extract orally for 28 days, and on the 29th and 30th day, isoprenaline (85 mg/kg b. wt) was subcutaneously applied to induce MI. On the thirty-first day, the animals were killed, and serum and heart tissue homogenates were used to assess several biochemical markers. Treatment with CS extract greatly (p < 0.05) reduced the elevated levels of serum cardiac markers, including troponin-T, lactate dehydrogenase (LDH), and creatine kinase-MB (CK-MB). It also enhanced the antioxidant status by raising the levels of catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA). Histopathological examination of the heart tissues revealed a significant reduction in the extent of myocardial damage in the CS-treated groups. Over all our study provides evidence that the ethanolic extract of Clerodendrum serratum leaves exhibits cardioprotective activity against isoprenaline-induced MI by improving antioxidant status and reducing cardiac damage. Further investigations are needed to elucidate the active compounds and molecular mechanisms involved in the observed effects.
Keywords: Clerodendrum serratum, Bharangi, Phytochemicals, Cardioprotective Activity
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© Vignan’s University, Guntur
Jada Naga Lakshmi, Sreenu Thalla, Palaneedhi Chennaiah, P Siva Krishna, Puttagunta Srinivasa Babu. Cardioprotective Activity of Clerodendrum serratum In Attenuation of Myocardial Infarction Induced by Isoprenaline. Vig J Biotech Phar. 2025;1(1):40-46.